Are you suffering from chronic knee pain and looking for a non-surgical solution? The Brixton ICE Trial, led by Dr. Antony at The Orthopaedic Institute, is evaluating an investigational treatment designed to provide long-lasting pain relief for individuals who have tried conservative therapies but are not yet ready for surgery.

The Brixton ICE (ICE (Injectable Cold Energy) Trial is researching Neural ICE™ Therapy, a non-opioid, investigational injection that aims to help manage knee pain and improve mobility. This study offers eligible patients the opportunity to explore a potential new treatment option at no cost.

You may be eligible to participate if you:
✔ Have chronic knee pain due to osteoarthritis
✔ Have previously tried conservative treatments (e.g., physical therapy, medications, injections)
✔ Are looking for a non-surgical alternative for pain relief

✔ Study-related care at no cost
✔ Evaluation and treatment with Dr. Antony and his research team
✔ Close monitoring of your progress throughout the study

If you’re interested in learning more about this research study and whether you may qualify, contact our Clinical Research team today at (352) 224-4904.

Your participation could help shape the future of knee pain treatment while giving you access to a promising new option for relief. Spots are limited—reach out today!

Evidence-based medicine through clinical research has long been the foundation of expanding our understanding of medicine and guiding decision-making for patient care. We are proud to review here a new clinical research program at The Orthopaedic Institute in interventional pain medicine.

The field of interventional pain is expanding at a very rapid pace and at TOI we are on the cutting edge of newer, more effective, and less invasive options for our patients. As alternatives to less effective and sometimes dangerous medications, our minimally invasive procedures can serve as alternatives or as a complement to other surgical procedures such as spine surgery and joint replacement surgery. While all of our studies are funded, some offer patients access to therapies otherwise yet to be approved by regular insurance.

The goal of our clinical research program at TOI is to help understand new treatments and gain a better understanding of already established therapies. I serve as the Medical Director for Clinical Research and Gretchen Kostedt is our outstanding clinical research coordinator. Currently, we are participating in 8 funded studies making us one of the largest interventional pain clinical research programs in the Southeast. We are currently investigating new options in spinal cord stimulation, lumbar spinal stenosis, post-operative knee pain, peripheral nerve stimulation, and … sacroiliac joint dysfunction.

We expect to continue our growth as a national leader in clinical research for advanced interventional pain therapies in the years to come. For more information about specific research studies or if you have an interest in participating please contact Carole at (352)224-4904.

The Orthopaedic Institute features 10 state-of-the-art clinic locations and 
5 Express Ortho locations to serve our patients.